P240 Lower levels of bacterial aerobic respiration in sputum from people with cystic fibrosis with chronic lung infection

Bacterial aerobic respiration has recently been related to the outcome of antibiotic treatment in experimental studies, but clinical relevance levels bacterial remains be evidenced. Therefore, we hypothesized that is lower sputum from people with cystic fibrosis (pwCF) and chronic lung infection, where cure difficult rare, than patients acute respiratory tract infections (aLRTI), frequent. Oxygen (O2) consumption was measured by microrespirometry microprofiling newly expectorated 52 aLRTI cultures common pathogens. The further separated other mechanisms O2 potassium cyanide (KCN). In this study, active estimated compared previously published similar examinations pwCF infection. By inhibition KCN, mean determined account for 55% total (n = 12), which significantly higher (p 0.0087) addition, depletion more frequent when pathogens were detected 0.0048). We demonstrated infection patients. These variations physiology between may, at least part, contribute huge variation success two patient groups. Thus, potential function as a physiological determinant treatment.